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In this episode of the Silicon Valley Girl Podcast, Marina Mogilko sits down with Anne Wojcicki, co-founder and CEO of 23andMe — the genetic testing company that has helped more than 14 million people understand their ancestry and health risks, and built one of the largest human genetic datasets in the world.
After 23andMe went through bankruptcy and Anne Wojcicki lost control of the company she started in 2006, she fought to win it back at a court-approved auction and relaunched it as a nonprofit (TTAM Research Institute) — so no single pharma company would ever own your DNA.
In this conversation she breaks down what AI + your DNA can actually do for your health right now: predicting disease years before you feel it, the genetic risk factors everyone should test for, why the healthcare system is built to treat disease instead of preventing it, and the small daily habits that move the needle most.
She also opens up about the hardest year of her life — losing her sister, former YouTube CEO Susan Wojcicki, to lung cancer, going through bankruptcy, and why she refused to walk away. Plus: raising kids as a founder, having a baby at 45, co-parenting with her ex-husband Sergey Brin, and the single smartest thing you can do for your body in 2026.
*Timestamps:*
00:00 — Intro
00:55 — What AI + DNA can do today that a doctor couldn't 5 years ago
01:27 — Why the system pays to treat disease, not prevent it
02:00 — The cholesterol gene no diet can fix (Marina has it)
04:36 — Genetics vs. environment: how much can you actually control?
06:11 — "I'm 36 and don't want statins" — is there another way?
07:24 — The best health prompts to put into your AI right now
08:42 — Ad
09:52 — From 14 million to 100 million: training AI on human DNA
12:07 — What happens when we can predict cancer before it starts
13:16 — Connecting your wearable data to your genes
14:34 — The environmental factors quietly raising your risk
16:22 — Why small daily movement beats everything
17:22 — The one food society agrees is bad for you
18:20 — What changed for Anne after losing her sister Susan
22:52 — Why the next five years could be transformative
24:14 — Who should get genetic testing — and why no one should be surprised
26:39 — Baby KJ, CRISPR, and editing disease out of your genes
28:08 — A reality check on biotech, drug discovery, and the FDA
30:00 — The top things to do for your health after watching this
31:57 — Full-body MRIs, chest CTs, and catching things early
34:23 — Founder mindset: playing the 10+ year long game
38:00 — Rebuilding a town: community, kids, and downtown Los Altos
41:08 — "Did you ever think about giving up?"
43:59 — Her biggest lesson from the hardest year
46:56 — Having a baby at 45 and doing it her way
51:28 — Hard rules as a working mom
54:01 — Two ambitious founders, one marriage (on Sergey)
57:43 — The smartest thing you can do for your body in 2026
🧬 Anne Wojcicki:
Instagram: https://www.instagram.com/annewoj23/
X: https://x.com/annewoj23
LinkedIn: https://www.linkedin.com/in/anne-wojcicki
23andMe: https://www.23andme.com
*Links:*
📩 Follow my Newsletter (Future Proof): https://siliconvalleygirl.beehiiv.com/subscribe?utm_source=youtube&utm_medium=video&utm_campaign=futureproof-sub&utm_content=Anne-Wojcicki
🔗 Instagram: https://www.instagram.com/siliconvalleygirl/
𝕏 : https://x.com/siliconvalleymm
📌 My Companies & Products: https://Marinamogilko.co
#23andme #podcast #annewojcicki
